在接受抗逆转录病毒治疗的HIV阳性患者中,左心室透气功能障碍,全身炎症和胃肠道症状之间的关联
Madalina-Ianca Suba1,2, Bogdan Hogea3,4, Ahmed Abu-Awwad3,4
1Doctoral School, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Diseases (Basel, Switzerland)
|December 27, 2024
概括
患有左心室扩张性功能障碍 (LVDD) 的艾滋病毒患者经历了炎症和胃肠道 (GI) 症状的增加. 针对炎症,特别是TNF-α,可能会改善这些心血管和胃肠道并发症的结果.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 接受抗逆转录病毒治疗 (ART) 的艾滋病毒患者面临心血管和胃肠道 (GI) 问题的风险,原因是持续的炎症.
- 左心室扩张功能障碍 (LVDD) 在HIV中很常见,可能会恶化炎症和胃肠道症状.
研究的目的:
- 为了研究LVDD,全身炎症和GI症状在ART治疗的HIV阳性患者之间的关联.
- 确定LVDD如何导致炎症并影响该人口的胃肠道健康.
主要方法:
- 320名参与者的横截面研究:艾滋病毒+有LVDD (n=80),艾滋病毒+没有LVDD (n=120),以及艾滋病毒对照 (n=120).
- 测量了炎症生物标志物 (CRP,IL-6,TNF-α,纤维素,IL-1β,IFN-γ,D-二次体) 和胃肠道症状.
- 通过心声学评估LVDD;使用后勤回归来确定GI并发症预测因子.
主要成果:
- 患有LVDD的HIV+患者表现出较高的TNF-α,CRP和D-二元水平.
- 生物标志物升高与恶心,腹和腹痛增加相关.
- TNF-α是胃肠道症状的最强预测因子;单独使用ART并不能完全解决炎症/凝血问题.
结论:
- 患有LVDD的HIV患者具有显著的炎症负担,影响心血管和胃肠道健康.
- 解决心血管和胃肠道症状的综合管理至关重要.
- 针对TNF-α等炎症生物标志物可能会改善与艾滋病毒相关的并发症的临床结果.
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