相关实验视频

Updated: Jun 4, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

免疫检查点抑制剂相关的病:回顾性分析和文献综述

Malvika Gupta¹, Christopher Graham², Supriya Gupta²

¹Kasturba Medical College, Manipal Academy of Higher Education, Mangalore 575001, India.

Diseases (Basel, Switzerland)

|December 27, 2024

概括

免疫检查点抑制剂 (ICI) 治疗可以导致罕见的免疫媒介性乳病,与肠球炎不同. 无质饮食可以快速缓解症状,避免不必要的免疫抑制.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

免疫检查点抑制剂 (ICI) 通过增强抗瘤免疫力来治疗恶性瘤.
ICI治疗可能会导致免疫媒介的不良影响,包括罕见的胃肠道毒性.
免疫媒介性腹腔炎是一种未被认可的ICI毒性,模仿ICI诱导的肠球炎.

研究的目的:

通过ICI疗法诱导的免疫介导的乳性疾病的特征.
为了区分ICI诱导的腹腔炎和ICI诱导的肠球炎.
为了确定ICI诱导的腹病的最佳治疗策略.

主要方法:

从文献中回顾分析了8例ICI诱导的腹腔炎病例和24例ICI诱导的肠球炎病例.
对患者人口统计,临床病史,干预措施和结果进行比较分析.
评估临床表现,组织学发现和治疗反应.

主要成果:

与先前存在的自身免疫和HLA-DQ2阳性相关的ICI诱导的乳病.
显著的临床和组织学特征,包括十二指甲状腺小麻木,体重减轻和营养不足.
无质饮食导致了快速改善;免疫抑制疗法是无效的.

结论:

ICI诱导的乳病是一种罕见的胃肠道不良反应,经常被误诊.
早期诊断和无质饮食对于症状的缓解至关重要.
及时的无质饮食可以避免不必要的免疫抑制和停止免疫治疗.

关键词:

在 CTLA-4 中.在HLA-DQ2中.在PD-1中使用PD-1.在PD-L1中.负面影响负面影响患有乳性疾病的患者.肠道结肠炎肠道结肠炎没有质的无质饮食.免疫疗法免疫疗法

更多相关视频

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

相关概念视频

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...