甲在与癌症有关的神经病痛中:叙述性综述
Faten Ragaban1, Om Purohit1, Egidio Del Fabbro1
1Division of Palliative Medicine, Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Current oncology (Toronto, Ont.)
|December 27, 2024
概括
当其他治疗失败时,甲作为癌症相关神经病痛 (CRNP) 的首选阿片类药物显示出希望. 它为特定的患者群体提供独特的好处,包括患有功能障碍或混合疼痛类型的患者.
科学领域:
- 在瘤学瘤学.
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 癌症相关的神经病痛 (CRNP) 显著影响患者的生活质量.
- 对于CRNP存在有限的治疗指南,特别是在化疗诱导的外围神经病变 (CIPN) 外.
- 阿片类药物是CRNP的第三线选择,但对最有效的药物缺乏共识.
研究的目的:
- 自2006年最后一次全面审查以来,审查和更新CRNP中甲使用的文献.
- 评估甲在癌症患者中治疗神经病痛的疗效和安全性.
主要方法:
- 使用PubMed,谷歌学者和科克兰图书馆进行了全面的文献搜索.
- 关键词包括"甲和癌症疼痛和神经病痛"和"与癌症相关的阿片类药物治疗".
- 包括的研究包括在2000年至2024年间发表的RCT,系统性审查,元分析和观察性研究.
主要成果:
- 甲的独特作用机制和初步数据支持其考虑CRNP.
- 当非阿片类药物治疗无效时,它可以成为CRNP的第一线阿片类药物.
- 甲也适用于功能障碍,输卵管管理,财务限制或高剂量阿片类药物转换的患者的混合 nociceptive-neuropathic疼痛.
结论:
- 甲是CRNP的可行的第一线阿片类药物选择,特别是当其他治疗方法失败时.
- 特定的患者特征可能会要求甲作为一线选择.
- 需要进一步的研究,以充分阐明甲在CRNP亚组中的作用和最佳使用.
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