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Updated: Jun 4, 2025

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激活SIRT1通过TGF-β/Smad2/3通路抑制角膜内皮 - 介质细胞过渡

Yi Yu1, Ruilin Guo1, Jie Ling1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.

Current issues in molecular biology
|December 27, 2024
PubMed
概括

赛尔图因-1 (SIRT1) 激活通过调节转化生长因子-β (TGF-β) /Smad2/3通路来抑制角膜内皮-介质细胞过渡 (EnMT). 这一发现表明SIRT1激活是角膜内皮功能障碍的潜在治疗标.

关键词:
一个SIRT1系统.在TGF-β/Smad2/3/3中.角膜内皮细胞 角膜内皮细胞内皮半酶体过渡的内皮转移.

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