Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.0K
Fibril-associated Collagen01:11

Fibril-associated Collagen

2.4K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.4K
Mitochondria01:37

Mitochondria

8.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
8.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Comparative study of recovery characteristics between remimazolam anesthesia with flumazenil and desflurane anesthesia for closed reduction of nasal bone fracture: a randomized controlled trial.

Korean journal of anesthesiology·2026
Same author

Long-Term Effect of Intensive Education in Patients With First-Ever Ischemic Stroke.

Journal of the American Heart Association·2026
Same author

Human-Relevant In Vitro Skin Models: From Regulatory-Validated Platforms to Emerging Technologies for Translational Dermatology.

Experimental dermatology·2026
Same author

Postpartum stroke - disseminated intravascular coagulation associated with amniotic fluid embolism.

Obstetrics & gynecology science·2026
Same author

Intrarenal Hemodynamic Mechanisms of Kidney Protection by Nonsteroidal Mineralocorticoid Receptor Antagonists.

Endocrinology and metabolism (Seoul, Korea)·2026
Same author

Plasma Enabled Hierarchical Surface Reconstruction of Nanoengineered, Dendrite-Free Zn Metal for Durable Aqueous Zinc Ion Battery.

Small methods·2026
Same journal

Correction: Wang et al. Phosphatidylserine Decarboxylase Promotes Ferroptosis Through STAT3/GPX4 Signaling in Gastric Cancer. <i>Curr. Issues Mol. Biol.</i> 2026, <i>48</i>, 300.

Current issues in molecular biology·2026
Same journal

Exploring the Relationship Between Protein-Level Ratios (rQLTs) and Duodenal Ulcer.

Current issues in molecular biology·2026
Same journal

Metformin as an Innate Immune Modulator: Metabolic and Epigenetic Reprogramming of Innate Immune Cells and Therapeutic Implications.

Current issues in molecular biology·2026
Same journal

Comprehensive Bioinformatic Characterization of CD70, CD80, and TIGIT as Diagnostic, Prognostic, and Immune Biomarkers in Pan-Cancer.

Current issues in molecular biology·2026
Same journal

Genome-Wide Identification and Expression Analysis of the Thaumatin-like Protein Genes in <i>Filipendula ulmaria</i> under <i>Bipolaris sorokiniana</i> Infection.

Current issues in molecular biology·2026
Same journal

Recent Dominant Transposition Events Affect Gene Regulatory Regions, but Not Coding Sequences, in Polar and Brown Bear Genomes.

Current issues in molecular biology·2026
查看所有相关文章

相关实验视频

Updated: May 8, 2025

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
07:03

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

Published on: January 31, 2014

11.9K

发酵鱼类原蛋白通过减弱 AGE-RAGE 结合活性减少了与光衰老相关的原蛋白减少.

Seyeon Oh1, So Young Lee2, Jong-Won Jang1,3

  • 1Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.

Current issues in molecular biology
|December 27, 2024
PubMed
概括
此摘要是机器生成的。

发酵鱼类原蛋白 (FC) 通过减少先进的糖化终产品 (AGE) - AGE (RAGE) 受体结合来对抗皮肤光衰老. 这种作用降低了炎症,改善了皮肤的弹性和水分.

关键词:
AGERAGE 具有约束力的活动.先进的糖化最终产品.发酵的鱼类原蛋白

更多相关视频

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

6.8K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.0K

相关实验视频

Last Updated: May 8, 2025

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
07:03

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

Published on: January 31, 2014

11.9K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

6.8K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.0K

科学领域:

  • 皮肤病学 皮肤病学
  • 生物化学 生物化学
  • 分子生物学分子生物学

背景情况:

  • 紫外线 (UV) 辐射诱导皮肤的光衰老,其特点是纹和弹性降低.
  • 紫外线暴露会增加先进的糖化终产品 (AGE) - AGE (RAGE) 结合的受体,导致炎症和NF-κB激活.
  • AGE-RAGE通路是UV诱导皮肤损伤的关键调解者.

研究的目的:

  • 为了研究发酵鱼类原蛋白 (FC) 减轻皮肤光衰的潜力.
  • 确定FC是否可以降低AGE-RAGE结合活性及其下游炎症信号.
  • 评估FC对原体降解和皮肤结构部件的影响.

主要方法:

  • 在实验室中使用紫外线照射的角质细胞进行研究.
  • 使用紫外线照射动物皮肤模型进行体内研究.
  • 测试用于测量AGE-RAGE结合,TNF-α分泌,NF-κB转位,矩阵金属蛋白酶 (MMP) 表达和原水平.

主要成果:

  • FC显著降低了紫外线照射的角质细胞中的AGE-RAGE结合活性和TNF-α分泌.
  • 在紫外线照射皮肤中,FC抑制了NF-κB转位,并降低了MMP-1,MMP-3和MMP-9的表达.
  • FC治疗导致Smad2/3,原纤维积累,皮肤水分和弹性增加.

结论:

  • 发酵鱼类原蛋白 (FC) 有效地减轻紫外线照射引起的皮肤光衰老.
  • FC通过降低AGE-RAGE通路和相关的炎症信号来发挥其保护作用.
  • FC促进原蛋白合成,改善皮肤水分和弹性,为光衰老提供潜在的治疗剂.