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发酵鱼类原蛋白通过减弱 AGE-RAGE 结合活性减少了与光衰老相关的原蛋白减少

Seyeon Oh¹, So Young Lee², Jong-Won Jang^1,3

¹Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.

Current issues in molecular biology

|December 27, 2024

概括

发酵鱼类原蛋白 (FC) 通过减少先进的糖化终产品 (AGE) - AGE (RAGE) 受体结合来对抗皮肤光衰老. 这种作用降低了炎症,改善了皮肤的弹性和水分.

科学领域:

皮肤病学皮肤病学
生物化学生物化学
分子生物学分子生物学

背景情况:

紫外线 (UV) 辐射诱导皮肤的光衰老,其特点是纹和弹性降低.
紫外线暴露会增加先进的糖化终产品 (AGE) - AGE (RAGE) 结合的受体,导致炎症和NF-κB激活.
AGE-RAGE通路是UV诱导皮肤损伤的关键调解者.

研究的目的:

为了研究发酵鱼类原蛋白 (FC) 减轻皮肤光衰的潜力.
确定FC是否可以降低AGE-RAGE结合活性及其下游炎症信号.
评估FC对原体降解和皮肤结构部件的影响.

主要方法:

在实验室中使用紫外线照射的角质细胞进行研究.
使用紫外线照射动物皮肤模型进行体内研究.
测试用于测量AGE-RAGE结合,TNF-α分泌,NF-κB转位,矩阵金属蛋白酶 (MMP) 表达和原水平.

主要成果:

FC显著降低了紫外线照射的角质细胞中的AGE-RAGE结合活性和TNF-α分泌.
在紫外线照射皮肤中,FC抑制了NF-κB转位,并降低了MMP-1,MMP-3和MMP-9的表达.
FC治疗导致Smad2/3,原纤维积累,皮肤水分和弹性增加.

结论:

发酵鱼类原蛋白 (FC) 有效地减轻紫外线照射引起的皮肤光衰老.
FC通过降低AGE-RAGE通路和相关的炎症信号来发挥其保护作用.
FC促进原蛋白合成,改善皮肤水分和弹性,为光衰老提供潜在的治疗剂.

关键词:

AGERAGE 具有约束力的活动.先进的糖化最终产品.发酵的鱼类原蛋白

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