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一种含有克洛德罗纳特的新型合凝的物理化学和功能性质:一个比较的体外研究

Patricia P Wright^1,2, Elise S Diamond¹, Vignesh Selvaprithiviraj^1,2

¹School of Dentistry, The University of Queensland, Brisbane, Queensland, Australia.

International endodontic journal

|December 27, 2024

概括

开发了一种新的klodronate凝,作为含EDTA的化凝的替代品. 虽然表现出一些功能性质,但没有任何测试的凝有效地溶解了组织,并清除了涂抹层以创建滑行路径.

科学领域:

生物材料科学生物材料科学
牙科材料科学牙科材料科学
牙周内科医院牙周内科医院牙周内科医院

背景情况:

商业化凝通常含有EDTA,它可以与二酸盐 (NaOCl) 反应.
这种化学相互作用可能会损害NaOCl在牙周内科手术中的疗效.
开发一种非EDTA合凝对于优化治疗结果至关重要.

研究的目的:

开发一种新的基于克洛德罗纳特的凝,作为一种无EDTA的替代品.
为了评估克洛德罗纳特凝的物理化学特性.
为了比较klodronate凝与商业化剂的功能性质 (组织溶解和涂抹层去除).

主要方法:

使用聚乙烯糖醇 (PEG) 400和四二基隆酸盐制备了一个克洛德罗纳特凝.
测量了物理化学性质 (pH,粘度) 和NaOCl反应性 (自由可用的).
组织溶解和涂抹层去除能力被评估使用猪口腔粘膜和牙管,分别与NaOCl结合使用.

主要成果:

克洛德罗纳特凝具有高pH值 (11.34),并且与4%的NaOCl相比,NaOCl反应性有显著的,尽管很小的差异.
在组织溶解试验中,克洛德罗纳特凝和NaOCl混合物的疗效与单独4%的NaOCl相美.
涂抹层的去除程度中等,克洛德罗纳特凝达到5.8%的牙管开放,明显低于15%的EDTA (9.7%).

结论:

开发出来的克洛德罗纳特凝具有独特的物理化学特性.
虽然在组织溶解方面有效,但与EDTA相比,klodronate凝没有显示出优异的涂抹层去除.
没有一个测试的凝表现出最佳滑行路径创建所需的所有功能性质.

关键词:

艾达达 (EDTA) 是一个叫做EDTA的语言.结合剂凝是一种合剂凝.克洛德罗纳酸的使用方法涂抹层的去除涂抹层的去除组织溶解组织溶解粘度粘度粘度粘度粘度

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