在慢性病患者的身体功能背景下,探索多余细胞外液的生物标志物
Hyae Min Lee1, Jihyun Baek1, So-Young Lee1
1Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Republic of Korea.
Journal of personalized medicine
|December 27, 2024
概括
脑衍生神经营养因子 (BDNF) 可能作为慢性病 (CKD) 患者体液过载的生物标志物. 较低的BDNF水平与细胞外水的增加相关,这表明在非透析CKD中监测体积状态的潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
- 身体生理学 身体生理学
背景情况:
- 过多的液体是蛋白质能量浪费和慢性病 (CKD) 患者的不良结果的重要危险因素.
- 确定可靠的体积状态生物标志物对于管理CKD患者至关重要.
- 肌基因,特别是来自大脑的神经营养因子 (BDNF),正在被研究为液体平衡的潜在指标.
研究的目的:
- 验证来自大脑的神经营养因子 (BDNF) 作为评估非透析慢性病 (CKD) 患者体积状况的潜在生物标志物.
- 为了研究BDNF水平和细胞外水与身体总水 (ECW/TBW) 的比率在CKD患者之间的关系.
主要方法:
- 纳入了151名非透析的CKD患者.
- 使用生物阻抗分析测量身体成分,以确定ECW/TBW比率.
- 评估了身体表现 (手握力,步行速度) 和BDNF水平.
主要成果:
- 在BDNF水平和ECW/TBW比率之间观察到显著的负相关性 (r = -0.329,p < 0.001).
- 线性回归分析证实了BDNF和ECW/TBW比率之间存在显著的负关系,即使在多变量调整后也是如此.
- 患有较低ECW/TBW比率的患者表现出更高体能指标的趋势.
结论:
- 脑衍生性神经营养因子 (BDNF) 在非透析CKD患者中显示出与ECW/TBW比率的显著负面关系.
- 在这种患者群体中,BDNF显示为监测体积状态的潜在生物标志物.
- 需要进一步的研究来充分确定BDNF在CKD中管理液体平衡中的作用.
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