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中性粒细胞与淋巴细胞比率在缺血性中风中的预后影响

Santhiago Calvelo Graça¹, Tainá Mosca¹, Vivian Dias Baptista Gagliardi¹

¹Santa Casa de São Paulo School of Medical Sciences, São Paulo 01224-001, Brazil.

Journal of personalized medicine

|December 27, 2024

概括

中性粒细胞与淋巴细胞的比率 (NLR) 在缺血性中风患者中较高,并且随着中风的严重程度而增加. 这种炎症标志物与中风风险因素或治疗无关,这表明它在评估中风严重程度方面的有用性.

科学领域:

神经学神经学
免疫学免疫学免疫学
生物标志物生物标志物

背景情况:

中性粒细胞与淋巴细胞的比率 (NLR) 是炎症性疾病的潜在预后标志物.
缺血性中风涉及炎症过程,使得NLR成为预后评估的候选人.

研究的目的:

在不同亚型和严重程度的缺血性中风患者中量化NLR.
将NLR与中风风险因素,治疗相关联,并与健康个体进行比较.

主要方法:

从缺血性中风患者和健康对照组的临床和实验室数据的回顾性分析.
通过将中性粒细胞计数除以淋巴细胞计数来计算NLR.
使用NIHSS尺度对中风严重程度的评估.

主要成果:

与健康个体相比,缺血性中风患者的NLR值较高 (45%的NLR大于4,71%的NLR小于2).
在中风后的24小时和72小时内,NLR与中风严重程度 (NIHSS) 有显著的相关性.
小血管中风亚型显示了最低的NLR值.
没有发现NLR与中风风险因素,地形或治疗之间的联系.

结论:

在缺血性中风中,NLR升高,与中风严重程度直接相关.
对于评估缺血性中风的严重程度,NLR可能成为一个有价值的生物标志物.
NLR与常见的中风风险因素,地形或治疗方式无关.

关键词:

这是一种炎症炎症炎症炎症.缺血性中风中风作为一个中性恋者.预后预后预后

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