当前分析方法和临床诊断的挑战 侵袭性肺阿斯伯吉洛斯感染的临床诊断
Madeline C R Schwarz1, Alex E Moskaluk2,3, Joshua B Daniels2
1Department of Chemistry, Colorado State University, 1801 Campus Delivery, Fort Collins, CO 80523, USA.
迅速诊断侵袭性肺阿斯伯吉洛症 (IPA) 是至关重要的. 本综述审查了当前的诊断方法,以减少IPA.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 诊断技术 诊断技术 诊断技术
背景情况:
- 在免疫功能低下的患者中,侵入性肺阿斯伯吉洛症 (IPA) 的发病率不断上升.
- 高死亡率 (超过70%) 与IPA诊断延迟有关.
- 早期诊断可以将IPA死亡率降低高达30%.
研究的目的:
- 审查目前IPA的诊断技术.
- 评估每个方法的优点和缺点.
- 确定需要改进的领域,以加快IPA诊断.
主要方法:
- 审查已建立和新兴的IPA诊断技术.
- 培养,成像,PCR,PNA-FISH,ELISA,LFA和LC-MS的分析. 这是一个很好的方法.
- 评估诊断速度,分析和临床敏感度.
主要成果:
- 目前的诊断方法在诊断速度和灵敏度上有所不同.
- 有前途的进步存在,但需要进一步优化.
- 目前没有一种方法可以为所有情况提供最佳的速度和灵敏度.
结论:
- 更快,更敏感的IPA诊断方法是必不可少的.
- 对新的诊断方法的持续研究是有必要的.
- 改进的诊断将减少IPA死亡率并改善患者的治疗结果.
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