在COVID-19患者的横向传播中,Candida albicans在重症监护室住院的患者
Magdalena Skóra1, Katharina Rosam2, Magdalena Namysł3,4
1Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Czysta 18 Street, 31-121 Krakow, Poland.
Journal of fungi (Basel, Switzerland)
|December 27, 2024
概括
坎迪达阿尔比坎斯的水平传播发生在重症监护病房. 菌株在患者之间传播,可能是通过医疗保健工作者传播,在不同基因组中显示出一致的抗真菌易感性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 密集护理医学 密集护理医学
背景情况:
- 侵袭性角膜炎,主要是由白菌 (Candida albicans) 引起的,是一种显著的医院感染.
- 菌常常源于患者的内源性植物,促进了医院获得的传播.
- 在重症监护病房中,患有严重COVID-19的患者特别容易受到侵入性真菌感染的影响.
研究的目的:
- 调查在重症监护病房环境中,在重症COVID-19患者中水平传播Candida albicans的可能性.
- 分析从这些患者中分离出来的Candida albicans菌株的遗传相关性.
- 评估流通中的Candida albicans菌株的抗真菌敏感性概况.
主要方法:
- 从36名患者的血液和呼吸道样本中收集了59种Candida albicans菌株.
- 使用随机放大多态DNA (RAPD) 方法与OPA-18原料进行菌株的基因定型.
- 使用欧洲抗菌敏感性测试委员会 (EUCAST) 方法对关键抗真菌剂进行抗真菌敏感性测试.
主要成果:
- 根据RAPD模式确定了13个不同的Candida albicans遗传组.
- 观察到两个主要的克隆集群,其中一个由12名患者的17个菌株组成,另一个由7名患者的12个菌株组成.
- 所有经过测试的Candida albicans菌株都对安福特素B,可纳,伏利可纳和安尼杜拉金表现出敏感性,在遗传集群中具有类似的敏感性概况.
结论:
- 这项研究提供了证据,表明在重症监护病房内存在Candida albicans的水平传播.
- 由于数据有限,确切的传播途径尚不清楚,但医疗人员无意传播是可能的.
- 不同基因群体之间一致的抗真菌易感性表明流通菌株的共同来源或成功适应.
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