身体活动对,和联合暴露的影响
Akua Marfo1,2, Emmanuel Obeng-Gyasi1,2
1Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
Medical sciences (Basel, Switzerland)
|December 27, 2024
概括
环境中的金属暴露,如,和,会影响身体活动. 较高的组合金属含量与增加的体力活动有关,而是最有影响力的金属. 先进的方法揭示了复杂的暴露-反应关系.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 人体生理学 人体生理学
背景情况:
- 环境暴露,包括重金属,可以显著影响身体活动水平.
- 身体活动是整体健康的关键决定因素.
- 了解多种环境暴露的综合影响对于公共健康至关重要.
研究的目的:
- 调查,和联合暴露对身体活动的影响.
- 用先进的统计方法探索金属暴露的非线性和交互效应.
- 为了确定个体金属在预测身体活动中的相对重要性.
主要方法:
- 利用了2013-2014年国家健康和营养检查调查 (NHANES) 的数据.
- 使用ActiGraph GT3X+设备测量体力活动和金属含量通过感应合等离子体质谱学.
- 采用描述性统计,多变量线性回归和贝叶斯内核机器回归 (BKMR) 来进行分析.
主要成果:
- 线性回归显示了,暴露和身体活动之间的积极关联.
- 根据BKMR分析,是最具影响力的金属,其次是和,基于后置包含概率 (PIP).
- 较高的联合金属暴露通常与增加的体力活动有关,尽管在高水平时不确定性更大.
结论:
- 这项研究强调了多种环境金属对身体活动的复杂互动影响.
- 像BKMR这样的先进方法对于准确评估环境暴露对人类行为的影响至关重要.
- 这些发现强调了在环境健康研究和干预中需要考虑结合金属暴露的必要性.
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