代谢衰老是慢性阻塞性肺部疾病的风险增加
Claire J Guo1, Suneeta Godbole1, Wassim W Labaki2
1Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
慢性阻塞性肺病 (COPD) 与加速的代谢衰老有关,与自然衰老过程共享共同的代谢签名. 这种加速衰老与更严重的COPD疾病相关.
科学领域:
- 代谢学 代谢学 代谢学
- 衰老的研究研究.
- 肺部医学 肺部医学
背景情况:
- 衰老和慢性阻塞性肺病 (COPD) 显著改变了新陈代谢.
- 衰老和COPD代谢特征之间的关系尚不清楚.
- 调查与COPD相关的加速衰老至关重要.
研究的目的:
- 为了确定老化和COPD之间是否存在共同的代谢特征.
- 调查加速衰老和COPD之间的关联.
- 开发和验证一个代谢年龄得分.
主要方法:
- 分析了来自5704名COPDGene和2449名SPIROMICS受试者的血代谢数据 (1013种代谢物).
- 根据支气管扩展器后的螺旋计 (FEV1/FVC < 0.7) 定义了COPD.
- 开发并验证了使用弹性净回归的代谢年龄得分.
主要成果:
- 在验证队列中,代谢年龄得分与时间年龄 (r=0.8) 有很强的相关性.
- 加快衰老 (>7年) 的COPD患者表现出更严重的疾病.
- 衰老和COPD之间的共享代谢物明显高于预期 (p < 0.001),特别是在氨基酸和谷氨代谢中.
结论:
- 一个共同的潜在机制可能将衰老和COPD联系在一起.
- 慢性肺炎与代谢衰老的加速有关.
- 代谢分析提供了对COPD病原和衰老的见解.
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