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在患有MASLD的患者中减少了细胞内和细胞外循环的食后溶解体酸脂酶活性

Monica Mischitelli¹, Eleonora Poggiogalle², Giulia Tozzi³

¹Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

|December 27, 2024

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者在血液和血中表现出较低的溶酶酸脂酶 (LAL) 活性. 这种降低,特别是在PNPLA3变体的携带者中,损害了饭后甘油三的正常调节.

科学领域:

生物化学生化学
肝病学肝病学是一种肝病学.
代谢障碍代谢障碍代谢障碍

背景情况:

低禁食血液溶酶酸脂酶 (LAL) 活性与代谢性肝硬化症有关.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在代谢健康方面越来越令人担忧.

研究的目的:

在MASLD患者的口服脂肪耐受性测试 (OFTT) 之前和之后测量血液和血中的LAL活性.
调查LAL活性,MASLD和帕塔丁类脂酶3 (PNPLA3) 变体之间的关系.

主要方法:

使用度法评估血液和血中的LAL活性.
在17名MASLD患者和26名对照人群中进行了OFTT.
通过RT-PCR对PNPLA3 rs738409变异进行基因型测定.

主要成果:

与对照组相比,MASLD患者的禁食和食后血液LAL活性显著降低,特别是那些具有PNPLA3变异的患者.
血细胞外LAL活性也降低了MASLD患者在禁食和食后状态.
在MASLD患者中没有LAL活性和食后甘油三之间的负相关性,但在对照组中存在.

结论:

无论吃什么,MASLD患者在血液和血中都有LAL活性降低.
该研究强调了MASLD中循环LAL水平和食后高甘油三血症之间的正常反向关系的丧失.
这种PNPLA3变异似乎影响了在MASLD中观察到的LAL活性差异.

关键词:

在PNPLA3的多态化中.lysosomal 酸脂酶的作用是什么代谢功能障碍代谢功能障碍代谢灵活性代谢灵活性

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