糖尿病与术后认知功能障碍之间的关联:系统性审查和元分析
Hongbo Liu1,2, Jiali Chen2, Jitao Ling3
1Jiujiang Clinical Precision Medicine Research Center, Jiujiang, China.
International journal of surgery (London, England)
|December 27, 2024
概括
糖尿病 (DM) 显著增加了术后认知功能障碍 (POCD) 的风险. 这一元分析证实,糖尿病患者更容易患POCD,特别是老年人和接受非心脏手术的人.
科学领域:
- 医学研究 医学研究
- 临床流行病学临床流行病学
- 神经科学是一个神经科学.
背景情况:
- 手术后认知功能障碍 (POCD) 是手术后的常见并发症,特别是心脏手术.
- 确切的POCD的原因还没有完全理解.
- 糖尿病与认知障碍有关,但其在POCD中的作用尚不清楚.
研究的目的:
- 调查糖尿病 (DM) 与患上术后认知功能障碍 (POCD) 的风险之间的关联.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行了系统的文献搜索,截至2023年9月.
- 分析了38项涉及8748名参与者的试验数据.
- 根据PRISMA和AMSTAR指南评估了研究质量,异质性和出版偏差.
主要成果:
- 与非糖尿病患者相比,糖尿病患者的POCD发病率高出1.44倍.
- 65岁以上的糖尿病患者 (RR: 1.69) 和那些接受非心脏手术 (RR: 2.01) 的POCD风险增加.
- 与非心脏手术患者相比,接受心脏手术的糖尿病患者的风险较低 (RR:1.33).
结论:
- 糖尿病患者患POCD的风险显著增加.
- 需要进一步的研究来阐明这种风险增加背后的机制.
- 研究糖尿病人群中POCD的预防策略至关重要.
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