在开始服用ADHD药物之前是否需要常规QTc间隔查的评估:来自大型回顾性研究的经验
Hamza A Alsayouf1, Lima M Dyab2, Redab Al-Ghawanmeh3
1Dr Hamza Alsayouf Clinic, Amman 11181, Jordan.
Pediatric reports
|December 27, 2024
概括
在服用ADHD药物之前的常规心电图 (ECG) 可能对没有心脏病史的健康儿童不必要. 需要进一步研究低风险儿科患者的长期影响.
科学领域:
- 儿科神经学 儿科神经学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在开始儿童注意力缺陷/多动症 (ADHD) 药物治疗之前,关于常规心电图 (ECG) 存在争议.
- 本研究通过分析纠正的QT (QTc) 间隔数据来研究治疗前ECG的必要性.
研究的目的:
- 在开始服用ADHD药物之前,评估基线心电图在儿科患者的临床实用性.
- 在现实环境中评估治疗期间的QTc间隔数据和心脏安全.
主要方法:
- 对362名患有ADHD的儿科患者 (2-18岁) 进行了回顾性图表审查,有或没有自闭症谱系障碍 (ASD).
- 患者没有已知的心脏病或家族病史,并接受多动症治疗药物 (阿托莫克西丁,甲基酸盐,RISPERIDONE,ARIPIPRAZOLE),随访时间≥6个月.
- 进行了基线心电图和定期临床检查.
主要成果:
- 平均基线QTc间隔为400 ± 22毫秒. 一名患者超过了460毫秒的门,并被排除在治疗之外.
- 在随访期间,没有患者表现出心脏不良影响的迹象或症状.
- 大多数患者 (79.0%) 患有并发性ASD和ADHD.
结论:
- 在开始服用ADHD药物之前,对于没有心脏病史的健康儿科患者,常规查心电图可能不必必做.
- 需要进一步研究ADHD药物在低风险儿科群体中对心脏的长期影响.
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