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在犬类皮肤状细胞癌中Syndecan-1和E-Cadherin的表达

Rita Files¹, Cláudia Cardoso¹, Justina Prada^1,2

¹Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.

Veterinary sciences

|December 27, 2024

概括

降低的合成素-1 (CD138) 和E-cadherin表达与狗皮肤状细胞癌 (CSCC) 的攻击性增加相关. 斯特罗姆 syndecan-1 阳性与狗的较高瘤等级有关.

科学领域:

兽医病理学兽医病理学
在瘤学瘤学.
生物标志物发现发现

背景情况:

狗皮肤状细胞癌 (CSCC) 是一种局部侵袭性瘤,通常与皮肤颜色差的皮肤暴露在阳光下有关.
辛德肯-1 (CD138) 和E-cadherin对上皮组织功能和细胞粘附分别至关重要.
这些蛋白质的失调与各种癌症的预后不佳有关,突出了它们作为诊断和预后标记物的潜力.

研究的目的:

评估犬类皮肤状细胞癌 (CSCC) 中的Syndekan-1 (CD138) 和E-cadherin的表达.
确定这些生物标志物的表达水平与瘤攻击性和犬类CSCC等级之间的关联.

主要方法:

在47只狗的CSCC组织样本中,对syndecan-1 (CD138) 和E-cadherin表达的免疫组织化学分析.
生物标志物表达强度和定位与瘤等级和临床数据的相关性.

主要成果:

随着瘤的攻击性增加,Syndecan-1 (CD138) 的强度下降.
斯特罗马尔syndecan-1阳性与犬类CSCC中较高的瘤等级有显著的关联.
随着瘤恶性病变的增加,E-cadherin的强度也下降了,但其与syndecan-1的关联在统计学上并不显著.

结论:

减少的E-cadherin表达和积极的 stromal syndecan-1 (CD138) 染色似乎与狗皮肤状细胞癌 (CSCC) 的攻击性增加有关.
这些发现表明,syndecan-1和E-cadherin可能是犬类CSCC瘤进展的潜在指标.
需要进行进一步的研究,以阐明Syndecan-1和E-cadherin在犬类CSCC的病变发生过程中的确切作用.

关键词:

这是E-cadherin.攻击性攻击性攻击性皮肤状细胞癌瘤这些狗狗狗狗狗狗狗.这就是Syndecano-1的作用.

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