-葡萄糖共运输体2抑制剂和对比诱导的脏病风险:一个元分析
Gang Fan1,2, Lin Lin3, Hong Zuo4
1Cardiology Department of Xianyang Central Hospital, Xianyang, Shaanxi Province, 712000, People's Republic of China. nfgcardiology@126.com.
European journal of clinical pharmacology
|December 27, 2024
概括
-葡萄糖携带载体2抑制剂 (SGLT2is) 显著降低了对比诱导性病 (CIN) 和患者的死亡率. 需要进一步的研究来证实这些发现在非糖尿病人群中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 对比引起的脏病 (CIN) 是对比介质的管理后的一个显著风险.
- 目前对CIN的治疗方法有限,主要依赖于补水.
- 需要有效和安全的药物来预防CIN.
研究的目的:
- 进行一项元分析,评估-葡萄糖共运输体2抑制剂 (SGLT2is) 预防CIN.的保护潜力.
- 评估SGLT2is在降低CIN发病率和相关死亡率方面的有效性.
主要方法:
- 在PubMed,Web of Science和CNKI数据库中进行了全面的文献搜索,截至2024年8月26日.
- 数据分析使用R和Stata软件中的"Meta"包进行.
- 包括的研究包括11个回顾性和1个前性队列研究.
主要成果:
- 在SGLT2中,CIN发病率显著降低 (OR 0.39,P < 0.0001).
- 在接受SGLT2is治疗的患者中,死亡率也显著降低 (OR 0.45,P = 0.0039).
- 在持续置换疗法 (CRRT) 的需要或给予的对比体积方面没有观察到显著差异.
结论:
- SGLT2显著降低了CIN发病率,特别是在糖尿病患者中.
- 这些发现表明SGLT2是预防CIN的有希望的治疗策略.
- 建议进行大规模随机对照试验,以验证这些结果,并探索非糖尿病患者的结果.
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