种族作为乳腺粘膜癌的预后因素
Dingyuan Wang1,2, Yang Wang1, Songlin Gao3,4
1Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Journal of cancer research and clinical oncology
|December 27, 2024
概括
种族影响乳腺粘膜癌 (BMC) 的预后. 亚裔美国患者的存活率更高,而黑人和白人患者的存活率更低. 治疗应该考虑个性化护理的种族因素.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 乳腺粘膜癌 (BMC) 很少见,这使得预后研究在不同人群中具有挑战性.
- 来自移民人口的流行病学数据可以提供有关BMC种族差异的见解.
- 个性化临床指导方针是需要的罕见恶性瘤,如BMC.
研究的目的:
- 调查不同种族/种族群体乳腺粘膜癌 (BMC) 的预后差异.
- 利用移民人口数据来理解BMC生存结果.
- 为BMC管理制定量身定制的临床实践指南提供信息.
主要方法:
- 对来自中国的208名BMC患者和来自SEER数据库的10,322人的比较分析.
- 跨种族/族群的临床病理学数据,治疗和生存结果的统计比较.
- 对相关患者和瘤特征进行调整的生存分析.
主要成果:
- 亚裔美国人BMC患者年轻,瘤特征更有利.
- 亚裔美国人BMC患者的整体存活率 (OS) 比黑人和白人患者要好得多.
- 化疗仅在黑人BMC患者中改善了OS,而不是其他人.
结论:
- 种族是乳腺粘膜癌 (BMC) 的独立预后因素.
- 与中国患者相比,美国黑人和白人BMC患者的生存状况更差.
- 骨髓瘤治疗指南应纳入种族特异性预后因素.
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