皮里多克辛在妇科 laparoscopic 手术中预防术后恶心和吐:双盲随机对照试验
Qirui Zhang1, Xuyang Ye1, Shuqing Shi2
1Department of Anesthesiology and Hunan Province Key Laboratory of Brain Homeostasis, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Anesthesiology
|December 27, 2024
概括
皮里多 (维生素B6) 在妇科腹腔镜手术患者中显著降低了术后恶心和吐. 这一发现表明,维生素B6是手术后恶心和吐的潜在预防剂.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 手术后恶心和吐 (PONV) 是妇科腹腔镜手术后的常见并发症.
- 素 (维生素B6) 是推的一线治疗妊娠中恶心和吐的药物,但其在预防PONV方面的有效性尚未得到充分证实.
研究的目的:
- 评估皮里多克辛在接受选择性妇科腹腔镜手术的患者中预防术后恶心和吐的疗效.
主要方法:
- 一项随机对照试验,涉及240名年龄在18-65岁的患者,在全身麻醉下接受妇科腹腔镜手术.
- 在麻醉诱导之前,患者接受了氧素 (0.2g) 或正常盐水,以及标准的德克萨米他松和丹塞.
- 结果包括PONV的发病率,恶心,吐,疼痛和血清炎症标志物.
主要成果:
- 与对照组 (35.8%) 相比,素组 (16.7%) 的PONV发病率明显较低 (RR=0.47,P=0.001).
- 皮里多克辛特别减少了手术后恶心的发生率 (12.5%与35%,P<0.001),但没有显著影响手术后吐.
- 两组之间没有观察到疼痛,第一次PONV事件的时间或炎症标志物的显著差异.
结论:
- 皮里多克素,当与德克萨米他和丹塞一起使用时,有效地减少了在接受妇科腹腔镜手术的患者中PONV发病率.
- 需要进一步的多中心研究来验证这些发现在不同的人群中.
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