[慢性性中耳炎的术后期免疫调节疗法]
Z M Saidov1, Yu A Dzhamaludinov1, Kh M Diab2
1Dagestan State Medical University, Makhachkala, Russia.
Vestnik otorinolaringologii
|December 27, 2024
概括
亚克西默是一种氧化物.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性性中耳炎 (CPOM) 与细胞和幽默免疫和细胞因子配置的改变有关.
- tympanoplasty 是 CPOM 的外科手术,手术后的免疫状态需要调查.
研究的目的:
- 评估阿佐克西默化物在CPOM患者的耳 tympanoplasty后的术后期的临床和免疫疗效.
- 评估阿佐克西默化物对CPOM患者免疫系统参数的影响.
主要方法:
- 49名患有中膜炎和上膜炎的患者接受了 tympanoplasty.
- 用CD标志物评估细胞和幽默免疫力.
- 测量了细胞因子水平 (IL-1b,IL-10,IFN-γ,TNF-α) 和C反应蛋白.
主要成果:
- 胸膜整形术后的患者表现出CD3/4+和CD3/8+细胞减少,CD16/56+和CD19+细胞增加,以及高水平的炎症性细胞因子 (IL-1b,IFN-γ,TNF-α) 和C反应蛋白.
- 氧化胺的使用倾向于使免疫调节指数 (CD4/CD8),细胞毒性指数 (CD8/NK),IFN-γ/IL-10比率和C反应蛋白水平正常化.
结论:
- 亚佐克西默化物在CPOM患者的胸膜整形术后显示出免疫性作用.
- 亚佐克西默化物可以被推作为 CPOM 的术后治疗的辅助疗法.
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