在8周抗精神病治疗期间对女性精神分裂症的多模式连接模式的影响
Shuzhan Gao1,2, Yunkai Sun3, Fan Wu1
1Department of Psychiatry, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Schizophrenia bulletin
|December 27, 2024
概括
女性精神分裂症的结构和功能连接 (SC-FC) 合异常可能会通过抗精神病治疗正常化. 这种SC-FC合可以预测治疗反应,并确定治疗的关键脑点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症与异常的结构连接 (SC) 和功能连接 (FC) 相关.
- 在女性精神分裂症中,跨模体SC-FC关联及其通过抗精神病治疗的调制尚未得到充分理解.
- 这项研究研究了在治疗前和治疗后的女性精神分裂症患者的SC-FC合.
研究的目的:
- 在女性精神分裂症患者中研究SC-FC合.
- 为了确定抗精神病治疗是否使SC-FC合正常化.
- 探索SC-FC合作为治疗反应的生物标志物.
主要方法:
- 磁共振成像 (MRI) 用于评估SC和FC在64名女性精神分裂症患者和55名健康对照 (HCs) 中.
- 基于网络的统计分析了在基线和8周抗精神病治疗后的SC-FC合.
- 弹性网逻辑回归模拟治疗疗效预测.
主要成果:
- 与HC相比,女性精神分裂症患者在基线显示异常的SC,但没有FC.
- 抗精神病治疗改变了SC和FC的皮层-皮层,前-边缘,前-状,边缘-状和边缘-大脑连接.
- 基线SC-FC合在患者中高于HC,趋向于治疗后的正常化.
- SC和FC模式预测了心理病理和认知障碍的变化.
结论:
- 在女性精神分裂症中,SC-FC合可以作为抗精神病治疗反应的预测生物标志物.
- 特定的大脑连接 (皮层-皮层,前端-边缘等) 是抗精神病药物的潜在治疗点.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
59
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
59
Biological Causes of Schizophrenia
44
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
44
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
442
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
442
Antidepressant Drugs: MAOIs and Other Agents
194
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
194


