由于体外血源性骨髓炎的并发症的患病率
Blaise Cochard1,2, Asia Ciprani3, Marco Cirillo4
1Pediatric Orthopaedic Unit, Pediatric Surgery Service, Geneva University Hospitals, Geneva, Switzerland.
The Journal of bone and joint surgery. American volume
|December 27, 2024
概括
过体质血源性骨髓炎 (THO) 在13%的儿科病例中会导致生长障碍. 诸如血栓缩,白细胞病变和细菌毒性等因素影响这些并发症,影响长期的肢体发育.
科学领域:
- 儿科整形外科 儿科整形外科
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 透体血源性骨髓炎 (THO) 是儿童骨感染的重要原因之一.
- 由于生长软骨的参与,THO可以导致生长障碍,四肢长度差异和角形变形.
研究的目的:
- 确定与THO相关的并发症的患病率.
- 确定影响这些并发症发生的因素.
主要方法:
- 在17年内对89名THO患者的回顾性分析.
- 审查临床,生物,细菌学数据和MRI扫描,以检查生长板的参与.
- 通过放射性检查监测体皮软骨的生长.
主要成果:
- 在15%的血源性骨髓炎病例中,THO发生,主要影响远端骨和骨.
- 对甲素敏感的黄金葡萄球菌 (Staphylococcus aureus) 和金氏菌 (Kingella kingae) 是常见的病原体;12.4%的MSSA菌株存在毒性因素.
- 在13%的THO患者中观察到生长并发症,受血小板缺血,白细胞症和毒性因素的影响.
结论:
- THO对所有年龄组的儿科患者产生影响.
- 增长障碍发生在13%的THO病例中.
- 深度血小板缺血,白细胞瘤和特定的细菌毒性因子 (Agr,TSST,PVL) 与并发症风险增加有关.
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