乌干达年轻妇女的骨密度变化使用基于tenofovir的艾滋病毒暴露前预防和depotmedroxyprogesterone acetate避孕药
Renee Heffron1,2, Timothy R Muwonge3, Katherine K Thomas2
1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
AIDS (London, England)
|December 27, 2024
概括
在12个月内,使用注射DMPA (depot medroxyprogesterone acetate) 和PrEP (暴露前预防) 的年轻女性的骨矿物质密度 (BMD) 在12个月内下降了1-3%,而未使用两者的人则有所下降.
科学领域:
- 生殖健康 生殖健康
- 预防传染病 预防传染病
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 可注射仓库美德酸 (DMPA) 是乌干达的一个常见的避孕药,该地区艾滋病毒的流行率很高.
- 在年轻女性中,DMPA和HIV暴露前预防 (PrEP) 的同时使用正在增加.
- 在这个人群中,DMPA和PrEP对骨矿物质密度 (BMD) 的联合作用尚不清楚.
研究的目的:
- 调查DMPA和FTC/TDF (口服PrEP) 的同时使用对乌干达年轻女性的BMD的影响.
- 为了比较使用两种药物和不使用任何药物的女性的BMD变化.
主要方法:
- 在乌干达坎帕拉进行了一项为期两年的前性研究,涉及499名16至25岁的女性.
- 每年进行双重X射线吸收计 (DXA) 扫描以评估BMD.
- 对DMPA和FTC/TDF的暴露被使用TFV-DP量化在干血斑点和DMPA注射记录中进行分类.
主要成果:
- 没有使用DMPA或PrEP的女性显示BMD增加.
- 一年持续使用DMPA和FTC/TDF与腰椎和部的平均BMD损失为1.04%,腿部部损失为1.77%.
- 与未暴露的女性相比,同时使用者显示了统计学上显著的BMD减少: -3.35%的腰椎 (P=.001) 和 -2.24%的整个部 (P=.009).
结论:
- 同时使用DMPA和FTC/TDF PrEP在12个月后,与未暴露的女性相比,BMD降低了1-3%的趋势.
- 可能需要进一步的研究来了解这种BMD减少的长期影响.
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