皮层病变通过非损伤性皮层的体积损失影响多发性硬化症的认知衰退
Eva A Krijnen1,2, Maureen van Dam1,3, Albulena Bajrami1,4
1MS Center Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Annals of clinical and translational neurology
|December 27, 2024
概括
在多发性硬化症 (MS) 中,皮层病变导致病变皮层比正常出现的皮层更稀薄. 在看起来正常的皮质中,特别是默认模式网络中,体积损失预测了未来的认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病,其特征是脱髓化和轴突损伤.
- 皮层病变和稀薄是MS的关键病理特征,影响大脑功能.
- 了解皮层变化和认知衰退之间的关系对于MS管理至关重要.
研究的目的:
- 为了研究皮质病变,皮质稀释和MS中功能性大脑网络中的体积损失之间的相互关系.
- 确定这些结构变化如何与MS患者的未来认知功能有关.
主要方法:
- 一项纵向研究涉及230名多发性硬化患者和60名健康对照.
- 3特斯拉MRI扫描在基线和神经心理评估在基线和5年的随访.
- 对体积和厚度进行分析的皮层区域,根据AI检测到的病变被分类为病变或正常出现的病变.
主要成果:
- 皮层病变在边缘和默认模式网络中最为普遍.
- 在大多数网络中,皮质稀释在病变中比正常出现的皮质更为明显.
- 在默认模式网络中出现正常的皮质的基线体积在随访时显著预测了认知功能障碍.
结论:
- 在多发性硬化中,皮层病变与病变皮层的较大稀释有关,而不是看起来正常的皮层.
- 在看起来正常的皮质中的体积损失,特别是在默认模式网络中,是随后认知衰退的强有力的预测因素.
- 皮层病变可能通过诱导相邻的正常外观皮层缩而间接导致认知能力下降.
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