抗化疗免疫治疗的眼表面状新生病通过I-125支臂疗法进行治疗
Michael Antonietti1, Nathan L Scott1, Basil K Williams2,3
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
Cornea
|December 27, 2024
概括
-125 (I-125) 支臂疗法有效地治疗了耐化学免疫治疗的眼表面状瘤 (OSSN). 当手术带来重大风险时,这种方法提供了一个安全的替代方案,导致瘤完全解脱和视力恢复.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
背景情况:
- 眼表面状瘤 (OSSN) 是角膜和结膜的恶性瘤.
- 传统的治疗包括化疗和免疫疗法,但可能会出现耐药性.
- 广泛的OSSN外科切除可能会带来重大风险.
研究的目的:
- 报告使用-125 (I-125) 支骨治疗治疗抗化疗免疫治疗的眼表面状瘤病变 (OSSN) 的管理.
- 为了评估I-125支臂疗法的疗效和安全性,用于对标准治疗无反应的OSSN.
主要方法:
- 一个36岁男性的病例报告,活检证明OSSN涉及大约70%的角膜表面.
- 最初的治疗包括局部干扰素alpha-2b,局部5-fluorouracil和局部mitomycin C,反应不完全.
- 患者最终接受了18毫米I-125支臂疗法斑块的治疗,该斑块放置了97小时 (提供50Gy).
主要成果:
- I-125支臂疗法导致OSSN在一个月内完全消失.
- 受影响眼睛的视力敏度改善到20/20.
- 患者在55个多月内保持无瘤状态,后部亚囊性白内障的晚期并发症通过化手术成功管理.
结论:
- I-125支臂疗法是一种有效和安全的替代品,用于抗常规化疗免疫治疗的内皮质OSSN.
- 当广泛的外科切除与高风险相关时,这种治疗方式特别有价值.
- 该病例证明了I-125支臂疗法成功的长期瘤控制和视力保护.
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