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Updated: Jun 4, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

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准P4HA1促进CD8+T细胞原始细胞向免疫记忆和全身抗瘤免疫力扩张

Shijun Ma1, Li-Teng Ong1, Zemin Jiang1

  • 1Genome Institute of Singapore, Agency for Science, Technology, and Research (A(∗)STAR), 60 Biopolis Street, Singapore.

Cancer cell
|December 27, 2024
PubMed
概括

研究人员确定了prolyl-4-hydroxylase 1 (P4HA1) 作为癌症中CD8+ T细胞耗尽的关键调节剂. 向P4HA1促进了全身抗癌免疫力和T细胞前体扩张,提供了一种新的免疫疗法策略.

关键词:
在CAR T细胞中,P4HA1 的使用情况.在PD-1中使用PD-1.T细胞耗尽的情况在T细胞的记忆中.癌症免疫疗法免疫疗法缺氧 缺氧是指缺氧的情况.线粒体中的线粒体.固体瘤是一种固体瘤.系统免疫力 系统免疫力

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