在中年癌症患者中非癌症死亡的风险分类
Tianwang Guan1, Yanting Jiang2, Peinan Tu3
1Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, Cancer Center, the 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou 510280, China; Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, Dongguan 523059, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China.
Journal of advanced research
|December 27, 2024
概括
中年癌症患者面临的非癌症死亡风险更高. 一个新的分类系统将24种癌症类型分为6个风险级别,以更好地管理非癌症死亡率.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 非癌症事件是癌症患者死亡的重要原因.
- 非癌症死亡风险及其在中年癌症患者中的分类仍然不清楚.
- 这项研究旨在分析中年人的24种癌症类型的非癌症死亡风险.
研究的目的:
- 综合分析24种不同类型癌症中中年患者非癌症死亡的风险.
- 在这些患者中开发非癌症死亡的风险分类系统.
- 为风险分层管理策略提供信息.
主要方法:
- 使用标准化死亡率 (SMR),绝对超额风险 (AER) 和竞争风险模型.
- 在1,082,030名中年癌症患者中评估了非癌症死亡风险.
- 开发了基于非癌症死亡风险 (危险比率) 的风险分类.
主要成果:
- 中年癌症患者的非癌症死亡风险增加 (SMR = 3.37).
- 在24种癌症类型中,15种非癌症原因超过了癌症死亡率.
- 1975年至2017年间,因非癌症原因的年龄调整后死亡率从2.3%降至1.4%.
- 建立了一个非癌症死亡的6类风险分类系统.
结论:
- 非癌症死亡风险较高,在中年癌症患者中存在显著差异.
- 一个新的风险分类系统有助于估计和管理非癌症死亡风险.
- 对非癌症死亡率的风险分层对于中年癌症患者至关重要.
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