产前暴露于二甲基stilbestrol对卵泡发育有多代影响
Rachael E Rogers1, Kate A Fowler1, Andrew J Pask1
1School of BioSciences, The University of Melbourne, Melbourne, 3010, Australia.
Scientific reports
|December 27, 2024
概括
乙醇 (DES) 暴露会加速雌性小鼠的卵巢衰老,导致跨代不孕症. 这种内分泌干扰物会影响卵泡的发育,可能会增加原发性卵巢功能不全的风险.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 乙醇 (DES) 是一种内分泌干扰化学物质 (EDC),与在子宫内暴露的后代的不孕症有关.
- 之前的研究表明,在母亲暴露于DES后,小鼠的多代生育能力下降.
- 导致DES诱导不孕症的卵巢功能障碍的具体机制尚不清楚.
研究的目的:
- 调查DES暴露是否会在女性后代中诱导原发性卵巢缺陷 (POI) 和多囊性卵巢综合征 (PCOS).
- 要确定这些卵巢影响是否是跨代的.
- 阐明卵巢功能改变在DES诱导的不孕症中的作用.
主要方法:
- 孕期小鼠接受了100μg/kg的DES暴露.
- 卵巢形态和卵泡动态在F1,F2和F3雌性后代中进行了评估.
- 分析了毛囊数量 (原始,次要) 和毛囊囊的存在.
主要成果:
- 与对照组相比,F1和F2代人表现出较少的原始毛囊和显著更多的次要毛囊,这表明毛囊发育加速.
- 在F3世代中没有观察到毛囊比例的显著差异.
- 暴露于DES并没有导致毛囊囊的发病率增加.
结论:
- 暴露于DES会加速卵泡生成,这表明与原发性卵巢缺陷 (POI) 相一致的表型.
- 这种加速的卵泡发育可能有助于在DES后代中观察到的生育率下降.
- 雌激素EDCs可以破坏卵巢卵泡发育,可能增加敏感女性POI的风险.
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