术前炎症负担指数用于预后,食道状细胞癌经历了彻底切除的预后
Qiang Zhao1, Liang Wang1, Xun Yang1
1Department of Thoracic Surgery, Hangzhou Institute of Medicine (HIM), Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, Zhejiang province, China.
Scientific reports
|December 27, 2024
概括
炎症负担指数 (IBI) 有效地预测了经过手术的食道状细胞癌 (ESCC) 患者的结果. 较高的IBI水平与更差的生存率相关,使其成为一种有价值的预后工具.
科学领域:
- 在瘤学瘤学.
- 炎症生物标志物 炎症生物标志物
- 手术瘤学手术瘤学
背景情况:
- 炎症负担指数 (IBI) 是众所周知的各种癌症的预测指标.
- 它在食道状细胞癌 (ESCC) 中的特殊作用需要进一步验证.
研究的目的:
- 为了验证IBI在ESCC患者进行彻底切除的预测能力.
- 评估IBI,临床特征和癌症特异性生存率 (CSS) 之间的相关性.
主要方法:
- 一项涉及408名ESCC患者的回顾性研究,分为初级和验证队列.
- 评估IBI与临床因素和CSS的关系.
- 构建和验证一个名ogram模型.
主要成果:
- IBI与瘤长度,血管侵袭,围神经侵袭和TNM阶段有显著的相关性.
- 决策曲线分析和ROC曲线证实IBI的预后价值优于其他血液学指数.
- 高IBI与5年CSS明显更差 (27.0%与59.1%) 相关.
- 多变量分析确定IBI作为一个独立的预后参数.
- 一个基于IBI的名录表显示了ESCC中的CSS的良好预测性能.
结论:
- 这项研究证实了IBI在ESCC患者进行彻底切除的预测意义.
- IBI可用于ESCC的术前评估,因为它与预后有很强的相关性.
相关概念视频
Esophageal Strictures-I: Introduction
35
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
35
Barrett Esophagus-I: Introduction
35
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
35
Barrett Esophagus-II: Clinical Manifestations and Management
69
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
69
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
26
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
26
Esophageal Strictures-II: Clinical Features and Management
18
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
18
Esophageal Perforation-II: Clinical Manifestations and Management
22
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
22


