与大脑体积和网络动态相关的结构性不平等在美洲的衰老和痴呆症中存在
Agustina Legaz1,2, Florencia Altschuler1,2,3, Raul Gonzalez-Gomez1,4
1Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Nature aging
|December 28, 2024
概括
较大的结构不平等与大脑体积和连接能力的减少有关,特别是在老龄化和痴呆症患者中. 这突显了社会差异对大脑健康的生物学影响,特别是在服务不足的人群中.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 社会学 社会学 社会学
背景情况:
- 结构性不平等,资源的不平等分配,影响健康结果.
- 结构性不平等对老龄化和痴呆的生物学影响,特别是在代表性不足的群体中,仍然不太清楚.
研究的目的:
- 研究结构不平等 (使用吉尼指数) 与大脑结构 (体积和连接性) 之间的关联.
- 在拉丁美洲和美国的健康个体和阿尔茨海默病和前叶退行症患者中检查这些关联.
主要方法:
- 对2,135名参与者的大脑体积和连接数据的分析.
- 神经成像结果与国家级和州级吉尼指数的相关性.
主要成果:
- 较高的结构不平等与大脑体积和连接能力的减少相关.
- 这些影响在拉丁美洲更为明显,影响了脑,前丘脑和海马区域.
- 在美国,在岛屿-单元和时间区域观察到较轻的效应,在阿尔茨海默病患者中更强烈的关联.
结论:
- 结构性不平等显著影响大脑衰老和痴呆症.
- 研究结果表明,宏观社会因素的生物嵌入.
- 强调需要针对服务不足的人群进行有针对性的干预,以减轻这些差异.
更多相关视频
09:01A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
Published on: May 7, 2014
10.1K
12:28Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
17.2K
相关概念视频
Biological Influences on Intelligence
70
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
70
Organization of the Brain
708
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
708
Alzheimer's Disease: Overview
444
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
444
Language and Cognition
322
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
322
Dementia
94
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
94
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
