在化疗前,乳腺癌患者的δ-catenin表达和全脑小世界网络之间的关系
Mingtuan Xue1,2, Wei Du1, Jiajun Cao1
1Department of Radiology, First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Xigang District, 116011, Dalian, China.
Scientific reports
|December 28, 2024
概括
乳腺癌患者表达高或低的δ-catenin表达显示出不同的大脑网络模式. 大脑连接的这些差异与认知和口头记忆功能的变化有关.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 乳腺癌会影响大脑的功能和结构.
- δ-catenin蛋白表达可能在癌症进展和神经变化中发挥作用.
- 休息状态功能磁共振成像 (rs-fMRI) 可以揭示大脑网络拓学的变化.
研究的目的:
- 在化疗前研究乳腺癌患者的δ-catenin表达水平和全脑网络拓学的关系.
- 为了确定不同的δ-catenin表达水平是否与特定的大脑成像特征和认知功能相关.
主要方法:
- rs-fMRI用于分析整个大脑的小世界网络属性.
- 105名乳腺癌患者被分为高 (DH) 和低 (DL) δ-catenin表达组.
- 为了进行比较,包括36名健康女性 (HC) 的对照组.
主要成果:
- 在DH,DL和HC组中观察到网络拓属性的显著差异.
- 与HC相比,在患者组和DL和DH组之间发现了节点效率,节点间距和中心度的变化,特别是在上边缘和下面的额头旋转中.
- 相关性分析显示了大脑区域 (尾状核,额叶) 和认知/语言记忆得分之间的关联.
结论:
- 乳腺癌患者的高低δ-catenin表达水平与独特的全脑网络拓模式有关.
- 网络隔离和集成功能的差异与改变的认知和口头记忆有关.
- δ-catenin表达可以作为乳腺癌患者神经认知变化的潜在生物标志物.
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