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2,3,7,8-四二二氧化 (TCDD) 在口腔发育过程中对免疫系统母胎界面的影响

Wang Yongkai^1,2, Zhang Shuhui^1,2, Ma Li^3,4

¹Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.51, Weiliu Road, Jinan, Shandong Province, 250021, China.

Journal of molecular histology

|December 28, 2024

概括

2,3,7,8-四二二氧化 (TCDD) 暴露会破坏母胎免疫平衡,可能导致口腔裂 (CP). 用弗莱恩德的完整辅助剂 (FCA) 治疗部分逆转了这些效应,这表明MFI免疫平衡是关键.

科学领域:

生殖免疫学生殖免疫学
发展性毒理学发展性毒理学
环境健康环境健康

背景情况:

2,3,7,8-四二二氧化 (TCDD) 是一种已知的破坏免疫平衡的环境污染物.
TCDD被认为是 palatal cleft (CP) 形成的一个因素.
母胎界面 (MFI) 在怀孕和免疫调节中起着至关重要的作用.

研究的目的:

调查TCDD是否通过破坏母胎界面 (MFI) 的免疫平衡来诱导口腔裂 (CP).
探索弗洛恩德的完整辅助剂 (FCA) 对TCDD诱导的MFI免疫力和CP的潜在保护作用.

主要方法:

C57BL/6J小鼠被暴露在TCDD中,有或没有FCA治疗.
分析包括组织学检查 (H&E),免疫细胞的流细胞计 (Th1,Th2) 和细胞因子水平的ELISA (IFN-γ,IL-4).
测量侧重于胎盘发育和 palatal 架附近.

主要成果:

暴露于TCDD显著减少了胎盘大小,血管化和MFI细胞面积,以及母体血液中的Th1/Th2细胞和关键细胞因子 (IFN-γ,IL-4) 的减少.
FCA治疗部分恢复了胎盘参数,并增加了Th1/Th2细胞计数,特别是Th2细胞,表明免疫调节作用.
FCA治疗也减少了口腔架之间的距离,表明潜在的缓解CP的发展.

结论:

通过破坏母胎界面 (MFI) 免疫恒温,TCDD可能会诱导口腔裂 (CP).
FCA治疗表明,它有可能抵消TCDD对MFI免疫力和胚胎发育的不良影响.
需要进一步的研究来阐明TCDD对MFI免疫调节的影响的确切机制.

关键词:

破裂的宫殿口.免疫系统的免疫系统.母胎基因相容性母胎基因相容性胎盘胎盘胎盘胎盘

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