预防性阿司匹林使用和高血压之间的关联使用NHANES 2011-2018数据
Zhiyi Lu1, Qi Zhang2, Xinyi Mei1
1Medical College, Wuhan University of Science and Technology, Wuhan, China.
Scientific reports
|December 28, 2024
概括
预防性阿司匹林使用,包括低剂量和高剂量,在40岁及以上的美国成年人中与高血压没有显著联系. 这项研究发现,阿司匹林使用与高血压患病率之间没有联系.
科学领域:
- 心血管疾病研究研究
- 高血压流行病学 高血压流行病学
- 药理学研究 药理学研究
背景情况:
- 之前关于阿司匹林使用,剂量和高血压相关性的研究不足.
- 关于阿司匹林和高血压的现有研究结果不一致.
- 在美国成年人口中进行综合评估的需要.
研究的目的:
- 评估在美国成年人中预防性阿司匹林使用和高血压之间的联系.
- 分析不同阿司匹林剂量 (低与高) 对高血压患病率的影响.
- 提供关于阿司匹林在高血压管理中的作用的可靠数据.
主要方法:
- 使用国家健康和营养检查调查 (2011-2018) 数据进行的横截面研究.
- 对美国40岁及以上成年人全国代表性样本的分析 (n=5297).
- 亚司匹林使用的分类 (没有,低剂量≤100毫克,高剂量>100毫克) 和高血压的定义 (静脉缩≥140毫米平或静脉缩≥90毫米平).
主要成果:
- 在阿司匹林使用组之间,高血压发病率没有统计学上显著的差异 (非阿司匹林:70.2%,低剂量:68.3%,高剂量:68.0%;p=0.71).
- 多变量逻辑回归显示,预防性阿司匹林使用与高血压之间没有关联 (OR 1.11;95% CI 0.89-1.38).
- 亚组和敏感性分析,包括排除糖尿病患者,证实了这些发现.
结论:
- 预防性阿司匹林使用,无论剂量如何,与美国成年人高血压的患病率没有显著的关联.
- 研究结果表明,目前的阿司匹林使用模式不会影响该人口的高血压率.
- 进一步的研究可能会探索阿司匹林在特定亚组或不同的心血管环境中的作用.
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