费舍尔比率与心力衰竭患者心脏功能障碍风险之间的相关性
Qing Fen Zhou1, Fan Yang2, Qiu Ya Lu2
1Department of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
BMC cardiovascular disorders
|December 28, 2024
概括
菲舍尔比率 (FR) 是氨基酸的度量,是预测心力衰竭 (HF) 和其结果的有价值指标. 较低的FR水平与HF患者的风险增加和预后较差有关.
科学领域:
- 心脏病学 心脏病学
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 慢性心力衰竭 (HF) 的死亡率和住院率很高,需要对心肌营养进行研究.
- 氨基酸 (AAs) 是细胞功能和生存的重要代谢物.
- 调查费舍尔比率 (FR),分支链与芳香氨基酸的比率,对于理解高频率有意义.
研究的目的:
- 为了研究血FR与心脏功能障碍之间的关联,在左心室喷射率 (LVEF) ≤50%的患者中.
- 评估FR在预测HF进展和不良事件中的预后价值.
主要方法:
- 在441名参与者 (213名HF患者,228名对照组) 中,使用液态染色学-并联质谱测量测量了血清AA水平.
- 心声学评估了LVEF和E/e'比率. 使用后勤和考克斯回归分析来确定FR与心脏功能障碍和预后的关联.
- 对HF患者进行前性跟踪,以寻找不良事件,并使用卡普兰-梅尔曲线和日志等级测试进行分析.
主要成果:
- FR指数从对照组逐渐下降到具有更高E/e'比率的HF患者 (P < 0.001).
- 在HF患者中,低FR独立与HF (OR:2.072) 和升高的LV填充压力 (E/e'>14) 相关 (OR:1.659).
- 降低FR值预测HF结果较差,包括HF终点事件 (HR: 1.949).
结论:
- 低FR是预测HF和左心室填充压力的独立风险因素.
- 在HF患者中,FR作为心脏功能和预后的有价值指标.
- 监测FR可能有助于心力衰竭的风险分层和管理.
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