在甲状腺功能低下症患者中评估血液学参数,炎症生物标志物和甲状腺激素
Marzieh Haghbin1,2, Fatemeh Razmjooei3,4,5, Fatemeh Abbasi3,4
1Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.
BMC research notes
|December 28, 2024
概括
血液学参数如血红蛋白,血红素和平均体质血红蛋白与甲状腺激素在甲状腺功能低下症中相关. 易斯 (Le) 血型也与甲状腺刺激激素 (TSH) 有关,有助于患者管理.
科学领域:
- 内分泌学和新陈代谢学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺功能低下症是一种甲状腺激素生产中断的疾病,显著影响患者的生活质量.
- 多种病因导致甲状腺功能低下,需要有效的查和预后工具.
研究的目的:
- 评估血液学参数和炎症生物标志物与甲状腺激素 (T3,T4,TSH) 之间的关系.
- 探索这些参数在甲状腺功能低下症的查和预后中的潜在用途.
主要方法:
- 对88名患有甲状腺功能低下症 (TSH>正常,阴性抗TPO抗体) 的横截面研究.
- 对ABO,Rh和易斯 (Le) 血型,全血细胞计 (CBC) 参数 (Hb,Hct,MCH) 和炎症标志物 (ESR,CRP,IL-8,NLR) 的分析.
- 血液学/炎症标志物与血清T3,T4和TSH水平之间的相关性分析.
主要成果:
- 在Lea血型 (非分泌) 和TSH (P=0.01) 之间发现了显著的相关性.
- 在血红蛋白 (Hb),血红素 (Hct) 和平均体质血红蛋白 (MCH) 与T3,T4和TSH之间观察到显著的相关性.
- ESR与T4显著相关 (P=0.020);单细胞计数与T3 (P=0.029);淋巴细胞计数与TSH (P=0.041).
- 在Rh,ABO血型,CRP,IL-8或NLR与甲状腺激素之间没有发现显著的相关性.
结论:
- 血液学参数包括Hb,Hct,MCH和Le血型,在甲状腺功能低下症中与甲状腺激素有显著的相关性.
- 这些血液学标志物可以作为医生在治疗甲状腺功能低下症时的宝贵工具.
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