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超级增强剂激活主转录因子NR3C1表达并促进胃癌中5-FU抵抗

Junxian Yu1,2, Mengdi Chen1, Qingqing Sang1

  • 1Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 28, 2024
PubMed
概括

超强增强剂通过激活核受体亚家族3组C成员1 (NR3C1) 来驱动胃癌中对5-甲 (5-FU) 的耐药性. 抑制NR3C1或破坏超级增强剂可以增强5-FU的敏感性.

关键词:
5 - - 甲的使用.在NR3C1中,它是NR3C1.胃癌 胃癌 是一种胃癌.阶段分离,阶段分离.超级增强剂是一种超级增强剂.

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