血清素受体基因变异对物质使用障碍的影响
Laith Al-Eitan1, Hana Abu Kharmah1, Mansour Alghamdi2,3
1Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, Jordan.
Annals of medicine
|December 28, 2024
概括
像HTR2A和HTR2B这样的血清素受体基因的遗传变异与约旦男性的物质使用障碍 (SUD) 有关. 特定的基因变异和单基因类型可能会影响SUD易感性和物质使用动机.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 药物使用障碍 (SUD) 是由遗传和环境因素影响的复杂疾病.
- 血清激素途径与SUD易感性有关,而血清激素受体基因中的遗传标记物是潜在的风险因素.
研究的目的:
- 调查约旦男性中五种血清素受体基因 (HTR1B,HTR2A/B,HTR3A/B) 和SUD中的多态性之间的关联.
- 识别与SUD风险相关的特定遗传标记和单元型.
主要方法:
- 对496名约旦男性SUD和496名健康对照进行了基因型鉴定.
- 测序用于分析HTR1B,HTR2A,HTR2B,HTR3A和HTR3B基因中的多态性.
- 进行了等位基和单位基关联分析,以及SNP与物质使用动机之间的相关性分析.
主要成果:
- 在rs9567735 (HTR2A) 和rs17586428 (HTR2B) 与SUD之间发现了等位基相关性.
- 在五个具有SUD风险的基因中观察到一个HTR2A单基因型和四个单基因型的显著关联.
- 特定的SNP (rs1923882和rs1150226) 与物质使用动机相关,rs1150226也与吸烟有关.
结论:
- 人类5-HT受体基因中的遗传变异可能会影响约旦人口对SUD的个体敏感性.
- 需要进一步研究更大的样本大小和额外的遗传变异来证实这些发现.
相关概念视频
Human Genetics
469
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
469
Substance Use Disorders Affecting Sleep
146
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
146
Drugs Affecting Neurotransmitter Release or Uptake
843
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
843
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
170
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
170
Antidepressant Drugs: MAOIs and Other Agents
157
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
157
G-protein Coupled Receptors
111.7K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
111.7K


