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科迪塞普斯军用多糖的发酵影响了肠道细菌LPS结构的形成,并改变了其抗原性

Jiahui Zhu¹, Jieming Chen¹, Jiafeng Chen¹

¹College of Food Science & Institute of Food Biotechnology, South China Agricultural University, Guangzhou, China.

Journal of food science

|December 28, 2024

概括

科迪塞普斯军用多糖 (CMP40) 改变肠道细菌的脂多糖 (LPS) 结构,减少炎症标志物. 这种从Vibrio parahaemolyticus,Salmonella enterica和大肠杆菌的LPS修饰提供了新的健康见解.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
生物化学生物化学

背景情况:

肠道细菌脂聚糖 (LPS) 通过肠肝轴转移可以引发全身炎症.
科迪塞普斯军用多糖体 (CMP40) 显示出减轻炎症反应的潜力.

研究的目的:

调查CMP40肠道发酵对细菌LPS.结构修饰的影响.
评估后续对免疫反应和炎症标志物的影响.

主要方法:

来自Vibrio parahaemolyticus,Salmonella enterica和肠毒性大肠杆菌的LPS的发酵与CMP40.0.
使用电喷离子质谱法 (ESI/MS) 分析LPS结构变化.
炎症媒介的量化 (NO,IL-1β,IL-6,TNF-α) 和基因表达分析.

主要成果:

CMP40发酵改变了从测试的细菌菌株中LPS的抗原性.
结构分析显示,CMP40可以从LPS中去除酸组或脂肪酸链.
观察到氧化 (NO) 和促炎性细胞因子 (IL-1β,IL-6,TNF-α) 的水平降低.
基因表达数据支持观察到的LPS结构修改.

结论:

CMP40有效地改变肠道细菌LPS结构,影响其抗原性.
这种由CMP40进行的结构调节导致炎症性免疫反应减少.
该研究提供了通过LPS调节对CMP40的健康益处的新见解.

关键词:

这是一种Cordyceps militaris多糖化合物.在LPS的结构上,LPS的结构结构是:发酵发酵发酵发酵影响健康的健康影响.炎症反应是一种炎症反应.

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