冠状酸及其衍生物针对MCCC1抗胰岛素耐药性及其对2型糖尿病小鼠的低血糖作用

Guiyan Huang1, Yu Lin1, Jianping Zhao2

  • 1College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215123, China.

概括

冠酸衍生物H26显示出改善的低血糖效应和药理动力学. 这项研究确定甲基克罗托诺伊尔-CoA核糖酶1 (MCCC1) 作为酸的直接结合标,为2型糖尿病治疗提供了新的途径.

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