多omics分析揭示了脂肪组织中的线粒体新陈代谢发生变化,这些新陈代谢功能障碍相关的脂肪肝炎患者的脂肪组织
Helena Castañé1, Andrea Jiménez-Franco1, Anna Hernández-Aguilera2
1Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Institut d'Investigació Sanitària Pere Virgili, Reus, Spain; Department of Medicine and Surgery, Faculty of Medicine, Universitat Rovira i Virgili, Reus, Spain.
EBioMedicine
|December 28, 2024
概括
内脏脂肪组织 (VAT) 中的线粒体功能障碍与代谢功能障碍相关的脂肪肝炎 (MASH) 有关. 这种功能障碍会破坏脂质代谢,影响肝脏健康和肥胖的疾病进展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 系统生物学 系统生物学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和脂肪性肝炎 (MASH) 是严重的健康问题.
- 脂肪储存和脂肪组织平衡与MASH的发展和进展密切相关.
研究的目的:
- 用系统生物学方法研究脂肪组织在MASH病变发生中的作用.
- 为了识别与MASH相关的肝脏和脂肪组织中的分子特征.
主要方法:
- 一项病例对照研究分析了来自100名减肥手术患者的肝脏,皮下脂肪组织 (SAT),内脏脂肪组织 (VAT) 和血.
- 组织学评估诊断出MASH,随后进行全幻灯片成像,脂管学,蛋白质学和组织样本的转录学.
- 还进行了等离子体脂组学和蛋白质组学.
主要成果:
- 肝脏分析揭示了MASH中炎症,线粒体功能障碍和脂毒性相互关联的途径.
- 在MASH患者中,SAT和VAT的脂肪细胞面积更大.
- 增值税蛋白质学和脂质学证实了肝脏病理与线粒体功能障碍之间的联系. 血脂组在MASH查中实现了高诊断精度 (AUC=0.919).
结论:
- 在VAT中线粒体功能障碍是与肥胖相关的MASH的一个关键特征.
- 这种功能障碍会破坏脂质代谢,对肝功能和疾病严重程度产生负面影响.
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