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相关概念视频

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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相关实验视频

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Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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骨纤维细胞通过两个不同的Notch2-依赖的调节程序控制边缘区域B细胞的运动和功能.

Anneka Allman1, Brian T Gaudette2, Samantha Kelly1

  • 1Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Immunity
|December 28, 2024
PubMed
概括

骨边缘区域B细胞需要Delta-like1 (Dll1) 痕配体才能正常运作. 这种信号调节细胞生长和迁移,对于对微生物的免疫反应至关重要.

关键词:
B 细胞 B 细胞 B 细胞没有口,没有口.化学反应的化学作用.纤维细胞的网状细胞.边缘区域边缘区域的边缘区域脊髓 脊髓 脊髓 是一个

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相关实验视频

Last Updated: Jun 4, 2025

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 发展生物学 发展生物学

背景情况:

  • 天生类似的脏边缘区 (MZ) B (MZB) 细胞对于对血液传播的病原体的快速反应至关重要.
  • 为加速MZB细胞响应而整合外部和内在因素的机制在很大程度上是未知的.

研究的目的:

  • 为了研究Delta-like1 (Dll1) Notch配体在调节MZB细胞生物学中的作用.
  • 阐明MZB细胞编程中涉及的下游信号通路.

主要方法:

  • 在小鼠中利用基因操纵来研究Dll1的功能.
  • 分析了与细胞生长和迁移相关的基因表达.
  • 研究了-1酸盐受体1 (S1PR1) 在B细胞局部化中的作用.

主要成果:

  • Dll1,但不是Dll4,来自脏纤维细胞的配体对于MZB细胞池大小,迁移和功能至关重要.
  • D111-Notch2信号控制着Myc-依赖的细胞生长和Myc-独立的细胞运动调节,包括S1PR1.
  • 缺少S1pr1会损害MZB细胞进入MZ,并在Notch信号退出时导致脏保留.

结论:

  • 通过Dll1-Notch2信号,专门的脏,为MZB细胞编程平衡状态和巡逻行为.
  • 保存的Myc-依赖和Myc-独立的Notch2-调节机制是MZB细胞功能的关键.
  • 这些发现对理解人类B细胞子集和淋巴瘤有意义.