在接受化疗免疫治疗的患者中,瘤和周围血液之间的响应生物标志物的结合
Wee Loong Chin1, Alistair M Cook2, Jonathan Chee2
1National Centre for Asbestos Related Diseases, Institute for Respiratory Health, Nedlands, WA 6009, Australia; Medical School, University of Western Australia, Crawley, WA 6009, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
Cell reports. Medicine
|December 28, 2024
概括
对间皮瘤的化学免疫疗法显示出有前途. 响应者在血液中具有更多的干状CD8+T细胞,与瘤变化有关,有助于治疗预测.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 基于的化疗与抗PD-L1抗体相结合,为间皮瘤治疗提供了潜在的潜力.
- 这种治疗的潜在免疫机制和预测生物标志物仍然不清楚.
研究的目的:
- 为了研究化疗免疫疗法的免疫机制反应在间皮瘤.
- 通过整合外周血液和瘤数据来确定预测性生物标志物.
主要方法:
- 周围血液单核细胞的时间过程RNA测序 (RNA-seq).
- 单细胞RNA-seq和T细胞受体测序 (TCR-seq).
- 从DREAM试验 (N=54) 中分析治疗前瘤转录组数据.
主要成果:
- 在响应者的外周血液中增加了CD8+ T效应器记忆 (TEM) 细胞的丰度,这些细胞具有类似干细胞的特性.
- 治疗后这些TEM细胞的扩张.
- 周围血液免疫细胞变化与瘤微环境转录状态之间的联系.
- 对周围血液和瘤数据的综合分析可以很好地预测反应.
结论:
- 周围血液免疫细胞动态,特别是CD8+TEM细胞,反映了瘤对化疗免疫疗法的反应.
- 整合多部件数据可以提高治疗反应的预测能力.
- 了解这些复杂的相互作用对于优化间皮瘤治疗策略至关重要.
相关概念视频
01:27Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K