内血管治疗与单独抗凝治疗用于亚急性阴茎骨髓深静脉血栓症
Qun Huang1, Xing Zhang1, Linjie Zhang1
1Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Vascular Center of Shanghai Jiao Tong University, Shanghai, China.
Journal of vascular and interventional radiology : JVIR
|December 28, 2024
概括
血管内治疗 (ET) 显著改善了早期症状缓解,并减少了亚急性阴茎上深静脉血栓症 (DVT) 患者中度至重度的血栓后综合征 (PTS). 与抗凝药相结合的ET与单独抗凝药相比显示了类似的安全结果.
科学领域:
- 血管医学 血管医学
- 干预心脏病学 干预心脏病学
- 血栓形成研究研究
背景情况:
- 亚急性阴骨上深静脉血栓症 (DVT) 构成患上血栓后综合征 (PTS) 的风险.
- 早期症状管理和预防慢性并发症在DVT治疗中至关重要.
研究的目的:
- 为了比较内血管治疗 (ET) 加抗凝剂与单独抗凝剂的疗效.
- 为了评估早期的症状缓解和中度至重度PTS在亚急性 iliofemoral DVT患者的发病率.
主要方法:
- 一项前性研究包括86名患有亚急性阴茎下垂体DVT (15-28天) 的患者.
- 患者被随机分配到ET加抗凝药 (n=49) 或仅抗凝药 (n=37).
- 评估的结果包括症状缓解,血栓清除,PTS率 (Villalta评分,VCSS) 和12个月后的安全事件.
主要成果:
- ET组在3天内显著改善了症状缓解 (P < .001).
- 在12个月后,ET组的Villalta分数较低 (P=.027),中度至重度PTS减少 (6.5%vs27.3%,P=.011),VCSS较低 (P=.004).
- 两组之间在出血事件,DVT复发或死亡率方面没有发现显著差异.
结论:
- 将ET添加到抗凝药中,显著改善了亚急性阴茎上垂体DVT的早期症状缓解.
- 在12个月后,ET可以减少中度至重度PTS的发生,而不会影响安全.
- 内血管疗法是对被选中患有亚急性阴茎上垂体DVT的患者有益的治疗选择.
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