中链甘油三和乳清蛋白分离物预加载对2型糖尿病血糖的作用:一种随机交叉研究
Pardeep Pabla1, Joanne Mallinson1, Aline Nixon1
1MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.
序列中链甘油三化物 (MCT) 和乳清蛋白分离物 (WPI) 的预加载降低了食后葡萄糖,改善了2型糖尿病 (T2D) 的血糖变异性. 这些效应与抑制食欲和增加有益激素有关.
科学领域:
- 代谢健康 代谢健康
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 营养预装可以减轻2型糖尿病 (T2D) 患者和没有2型糖尿病 (T2D) 患者的食后葡萄糖峰值.
- 以前的研究主要集中在单餐预装上,通常使用基于蛋白质的配方.
研究的目的:
- 评估顺序中链甘油三化物 (MCT) 和乳清蛋白分离物 (WPI) 预加载对T2D患者血糖的影响.
- 为了研究对食后,白天和24小时血糖控制以及血糖变异性的影响.
主要方法:
- 一项随机对照试验,涉及21名2型糖尿病参与者,经过3个24小时的时间.
- 干预措施包括饮用水 (CONTROL),MCT预加载,或餐前连续的MCT和WPI预加载.
- 使用连续血糖监测来评估血糖 (iAUC) 和血糖变化率 (%CV).
主要成果:
- 与对照组相比,连续的MCT和WPI预加载显著降低了食后葡萄糖外游和24小时血糖变异性.
- 这些干预措施增加了循环中的β-酸,YY (PYY) 和胃抑制性多 (GIP) 的水平.
- 在MCT + WPI干预后,主观食欲评级下降.
结论:
- 连续摄入MCT和WPI预加载有效降低食后葡萄糖,并改善T2D患者的血糖变异性.
- 观察到的好处与激素变化 (β-基酸盐,PYY,GIP) 和食欲抑制有关.
- 这一策略为T2D中血糖管理提供了一个有前途的方法.
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