鼻恶性瘤的行为:十年样本的回顾性研究
Tomas Kostlivy1, Petr Skopek1, Pavel Klail1
1Department of Otorhinolaryngology, University Hospital in Pilsen, Faculty of Medicine in Pilsen, Charles University, Czech Republic.
Neuro endocrinology letters
|December 28, 2024
概括
鼻癌 (NPC) 是鼻中最常见的恶性瘤,主要影响50岁以上的男性. 远程转移和晚期严重影响NPC存活率,而化学放射治疗改善了结果.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 鼻恶性瘤很少见,占耳鼻瘤恶性瘤的3%.
- 鼻癌 (NPC) 是最常见的类型,其次是淋巴瘤.
研究的目的:
- 评估原发性鼻恶性瘤 (NPC和淋巴瘤) 的年龄分布和行为.
- 分析十年的第三级医院患者队列中的生存预测因素和治疗结果.
主要方法:
- 在2012年至2022年间,对48名被诊断患有鼻恶性瘤的患者进行了回顾性队列研究.
- 收集的数据包括组织学,症状,吸烟状态,TNM分类和生存结果.
- 统计分析的重点是确定与生存相关的重要变量.
主要成果:
- 在76.9%的病例中诊断出NPC,男性比女性多5倍,通常在50岁以上的人群中.
- 远程转移 (p < 0.0001) 和晚期 (p = 0.0153) 是NPC存活的显著预测因素.
- 化学放射治疗和息治疗与NPC患者的疾病特异性生存率的改善有显著联系 (p = 0.0094; p = 0.0004).
结论:
- 鼻癌是主要的鼻恶性瘤,与淋巴瘤相比,它具有不同的人口和生存特征.
- 体重减轻和吸烟是与NPC相关的显著症状.
- 鼻恶性瘤的整体五年生存率为42.3%,观察到显著的基于性别的生存差异.
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