怀孕期间不同三个月内血红蛋白度和血压之间的相关性
Jinhua Wu1, Xialidan Alifu2,3, Haoyue Cheng2,3
1Zhoushan Maternal and Child Care Hospital, Zhoushan, China.
BMC pregnancy and childbirth
|December 28, 2024
概括
怀孕期间母亲的血红蛋白 (Hb) 水平与血压 (BP) 有关. 较高的Hb水平 (≥120 g/L) 和增加的Hb与高血压有关,而较低的Hb (<110 g/L) 与低血压有关.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇健康 孕产妇健康
- 心血管生理学心血管生理学
背景情况:
- 孕妇的血红蛋白 (Hb) 水平是怀孕期间营养状况的关键指标,表现出显著的波动.
- 在整个怀孕期间,母亲的Hb水平和血压 (血压) 之间的确切关系仍然不完全理解.
研究的目的:
- 调查不同季度母体血红蛋白度与妊娠期间血压变化之间的关联.
- 探索血红蛋白和血压参数之间的剂量反应关系和潜在的非线性影响.
主要方法:
- 利用来自中国舟山妇幼医院电子医疗记录系统 (EMRS) 的数据.
- 分析了8168名孕妇的数据,将怀孕分为七个不同的周期.
- 使用通用估计方程 (GEE) 和多重线性回归模型来评估关联.
主要成果:
- 孕妇的Hb水平从妊娠的第一到第二个三个月下降,然后增加,但没有达到初始水平.
- 较低的Hb (<110 g/L) 与第二和第三季度较低的缩血压 (SBP) 和腹缩血压 (DBP) 相关.
- 较高的Hb (≥120 g/L) 与三个月的SBP和DBP升高有关,观察到剂量反应效应.
- 怀孕期间的Hb度变化与血压水平呈正相关性,对DBP的影响比SBP更强.
- 在血红蛋白变化和SBP和DBP之间发现了显著的非线性关系.
结论:
- 孕妇的血红蛋白度与怀孕期间的血压有关.
- 超过120g/L的母体Hb水平,以及从第一到第三季度增加的Hb水平,需要密切监测,因为它们与高血压有关.
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