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在卵巢切除的老鼠模型中,LPL-RH抑制了骨损失
Wen-Jie Chen1,2,3, Xin-Liang Wang2, Yu-Fan Wang2
1Departments of Geriatrics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, P. R. China.
BMC microbiology
|December 28, 2024
概括
像Bifidobacterium animalis亚种这样的益生菌. 乳LPL-RH可以通过调节肠道细菌和免疫反应来治疗雌激素缺乏诱导的骨质溶解. 这项研究表明,LPL-RH抑制骨质细胞活性,并改善了卵巢切除的老鼠的肠道屏障功能.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 缺少雌激素导致微生物群依赖的骨解.
- 益生菌显示出治疗这种疾病的潜力,但机制需要澄清.
研究的目的:
- 提供益生菌作为骨质溶解辅助治疗的证据.
- 为了探索缺少雌激素的骨质溶解的病理生理学.
主要方法:
- 经过卵巢切除的斯普雷格-道利大鼠被用益生菌 (Bifidobacterium animalis亚种) 治疗. 乳糖 (LPL-RH),,或两者兼而有之.
- 评估了益生菌的骨质代谢效应和机械作用.
- 16S rRNA测序分析了肠道微生物组的变化.
主要成果:
- 通过降低关键信号通路 (RANKL/TRAF6/NF-κB/NFATc1/TRAP) 的调节,LPL-RH抑制了骨质细胞激活和骨损失.
- LPL-RH降低了亲骨质细胞的T细胞 (TH17),炎症分子 (LPS),并改善了肠道屏障功能.
- LPL-RH改变了肠道微生物组,减少了S24-7并促进了Prevotella和Bacteroides.
结论:
- 生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖LPL-RH可以抑制骨质细胞形成和骨质溶解.
- LPL-RH通过调节17型免疫和肠道微生物群来实现这一目标.
关键词:
生物细菌 (Bifidobacterium animalis) 的亚种. 牛奶公司 LPL-RH缺少雌激素导致的雌激素缺乏骨质细胞生成 (Osteoclastogenesis) 是一个过程.骨质溶解是一种骨质分解.绝经后的骨质疏松症 (PMOP) 是一种TH1717 的时间.更多相关视频
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