在代谢前状态中,代谢综合征的危险因素使用在健康查组的层次分类研究来评估
Se-Jun Park1, Yu Na Kim1, Byeong Kil Oh2
1Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
Scientific reports
|December 29, 2024
概括
早期识别患有代谢综合征 (MetS) 风险的个体是关键. 机器学习识别了高尿酸和非酒精性脂肪肝疾病的MetS前集群,预测了未来的MetS发展.
科学领域:
- 代谢健康 代谢健康
- 预防医学 预防医学
- 在医疗保健中的数据科学.
背景情况:
- 早期识别患有代谢综合征 (MetS) 风险的个体对于及时干预至关重要.
- 前代谢状态,不符合完整的MetS标准,构成严重的健康风险.
- 了解风险因素和进展对于制定预防策略至关重要.
研究的目的:
- 通过健康查数据,识别和描述处于前代谢状态的不同个体群.
- 评估各种生物标志物的预测价值和未来 MetS 发展的条件.
- 探索机器学习在预测前MetS风险方面的实用性.
主要方法:
- 利用了来自27,623名参与者 (年龄在20-50岁) 的数据的层次聚合集群.
- 包括基线和随访数据:年龄,静止心率 (rHR),血清尿酸 (UA),C反应蛋白 (CRP),肝酶,费里丁,非酒精性脂肪肝病 (NAFLD),牙周病和H. pylori感染.
- 采用卡普兰-梅尔和通用添加模型来评估受限平均存活时间 (RMST) 并确定发病贡献者.
主要成果:
- 具有非酒精性脂肪性肝病 (NAFLD) 和尿酸升高 (UA) 的群体表现出最高的MetS风险.
- 一个最初由中等风险个体组成的集群显示出高生物标志物水平和最差的MetS预后 (RMST:211天).
- 尿酸 (UA),C-反应蛋白 (CRP) 水平和静止心率 (rHR) 是对MetS发病率的重要贡献者.
结论:
- 机器学习有效地预测了MetS前状态,并识别了患有代谢综合征的高风险个体.
- 像UA这样的生物标志物的特定组合和像NAFLD这样的条件是未来MetS风险的关键指标.
- 早期检测和干预策略可以通过识别这些高风险的MetS前集群来告知.
更多相关视频
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
11.6K
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
10.6K
相关概念视频
01:24Obesity
291
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
291
01:24Overview of Lipid Metabolism
770
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
770
01:20Pathophysiology of Diabetes
780
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
780
01:19Overview of Carbohydrate Metabolism
507
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
507
01:18Metabolic States of the Body: The Postabsorptive State
188
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
188
01:36Carbohydrate Metabolism
10.5K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.5K