高甘油糖指数与晚期心血管代谢综合征有关
1Department of Cardiology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510120, China.
Scientific reports
|December 29, 2024
概括
三甘油糖 (TyG) 指数与成年人患晚期心血管代谢综合征 (CKM) 的风险更高有关. 较高的TyG指数水平与增加的CKM综合征患病率相关,表明其作为风险评估工具的有用性.
科学领域:
- 老年医学 老年医学
- 代谢综合征研究 代谢综合征研究
- 心血管健康研究 心血管健康研究
背景情况:
- 心血管代谢综合征 (CKM) 是一种复杂的老年病症,对其代谢关联的研究有限.
- 三甘油糖 (TyG) 指数是胰岛素抵抗的标志物,与晚期CKM综合征相关,尚未进行广泛研究.
研究的目的:
- 调查甘油三糖 (TyG) 指数与晚期CKM综合征风险之间的潜在关联.
- 探索TyG指数和晚期CKM综合征患病率之间的剂量反应关系.
主要方法:
- 这是一项采用国家健康和营养检查调查 (NHANES) (2011-2018) 数据的横截面研究.
- 包括7904名参与者,通过多变量逻辑回归和受限立方线 (RCS) 模型进行分析.
- 评估TyG指数四分位数和连续TyG指数与晚期CKM综合征风险之间的关联.
主要成果:
- 在增加TyG指数四分位数和晚期CKM综合征的风险之间观察到一个积极的关联.
- 多变量逻辑回归模型显示,连续TyG指数和高级CKM综合征之间存在显著的正相关性.
- RCS分析显示出线性,积极的关系,最高的TyG指数四分位数 (Q4) 显示了与最低 (Q1) 相比,晚期CKM综合征的几率比率 (OR=1.94) 显著增加.
结论:
- 高甘油三糖 (TyG) 指数水平与晚期心血管代谢综合征 (CKM) 的患病率增加显著相关.
- 泰格指数可以作为一种有价值和可访问的生物标志物,用于评估患有晚期CKM综合征的风险.
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