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结构性MRI研究Pareidolia和视觉幻觉在药物原始的帕金森病

Masakazu Ozawa^1,2, Tomotaka Shiraishi^3,4, Hidetomo Murakami^3,5

¹Department of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan. ozawa4510@gmail.com.

Scientific reports

|December 29, 2024

概括

帕金森病患者的脑缩与帕雷多利亚有关. 视觉幻觉在PD中涉及不同的大脑区域而不是pareidolia,为向治疗提供了洞察力.

科学领域:

神经科学是一个神经科学.
神经学神经学
医疗成像医学成像

背景情况:

视觉幻觉 (VH) 和pareidolia共享潜在机制,但在帕金森病 (PD) 中大脑区域参与方面有所不同.
了解这些区别对于开发针对PD相关幻觉的有针对性的干预措施至关重要.

研究的目的:

为了研究与药物先验帕金森病患者的pareidolia相关的特定大脑区域.
为了比较Pareidolia的神经相关物与PD视觉幻觉的神经相关物.

主要方法:

从104名以前没有服用过药物的PD患者获得结构性MRI扫描.
使用FreeSurfer分析了皮质下灰质和皮质表面体积.
帕雷多利亚使用噪音帕雷多利亚测试 (NPT) 进行评估.

主要成果:

在PD患者中,NPT得分与右丘脑,海马体,皮质和轨道前皮质缩相关.
在调整了手性后,这些发现是一致的.
帕雷多利亚包括自下而上的 (thalamus,皮层) 和自上而下的 (轨道前皮层) 处理缺陷,而VH主要涉及自下而上的区域.

结论:

帕金森氏症的帕雷多利亚与特定大脑区域的结构变化有关,包括涉及感官输入和更高层次认知处理的区域.
区分神经通路的pareidolia和PD视觉幻觉对于未来的治疗策略至关重要.

关键词:

轻微的幻觉小的幻觉帕雷多利亚 (Pareidolia) 是一个类似的词.帕金森病是帕金森氏症的一种疾病.基于表面的形态测量.视觉幻觉是一种幻觉.

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